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Hatieganu", Cluj-Napoca, Romania. Abstract Aim: to evaluate the therapeutic efficacy of oxaliplatin and to analyze the pharmacokinetics of both ultrafiltrable free and protein-bound platinum in patients with metastatic colon cancer.

Method: 60 patients with stage IV colon carcinoma received mean 4. Response rate, progression-free survival PFS and toxicity were evaluated.

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The median time of progression was 9. Cumulative neurotoxicity, vomiting and diarrhea, myelosuppression appeared in The mean Cmax and AUC of oxaliplatin increased cancer colon diarrhea a dose-related manner. The pharmacokinetics of platinum after oxaliplatin administration was triphasic characterized by a short initial distribution phase and a long terminal elimination phase.

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The clearance of ultrafiltrable platinum was relatively high and cancer colon diarrhea clearance of platinum from plasma and blood cells was relatively low, which is probably a reflection of the covalent binding of platinum to these matrices.

Conclusion: Oxaliplatin is active and well tolerated in patients with advanced colon cancer.

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With a relatively low interpatient variability, it is eliminated triphasically and the mean Cmax and AUC increases in a dose-related manner. These results provide a scientific basis for the safe and effective use of oxaliplatin in the clinic.

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